Neuroscience Behind Ibogaine

The Iboga root contains 12 active alkaloids including Ibogaine. Ibogaine is converted into a new neurotransmitter for your brain called noribogaine which has a long half life in the body, lasting around four months. Primary studies show that this can act as an organic SSRI-like antidepressant, while augmenting manifestations of glial cell line-derived neurotrophic factor (GDNF) for long-term mood benefits. This create a sort of positive feedback loop which is also theorized to be one of the factors behind its anti-addictive and anti-craving effect. GNDF is a powerful neuroprotective protein that protects a variety of different neurons, and has been shown to induce significant growth of dopaminergic neurons.

For recent clinical studies on Ibogaine, Iboga, and Noribogaine, the following links may help:

A study on the autoregulation of glial cell neutrophic factor (GDNF)



Read how Noribogaine elevates serotonin, as a natural anti-depressant.